ABSTRACT
Different clinical and epidemiological studies using dual-energy X-ray absorptiometry have shown an increased prevalence of low bone mineral density in patients with inflammatory bowel diseases. The aim of this study was to assess the correlation between bone density and the disease activity in patients with ulcerative colitis. In this cross-sectional study, 52 patients with ulcerative colitis [duration of the disease less than 5 years] were invited to our research center, Golestan province, northeast of Iran, during February 2012 up to August 2012. A demographic checklist and Simple Clinical Colitis Activity Index was completed for each patients and 5 cc of blood sample was taken after obtaining the informed consent. We used colorimetry method for measuring serum calcium, UV method for serum phosphorus and ELISA for serum vitamin D. Dual-energy X-ray absorptiometry was done to evaluate the bone density. Data analysis was done using SPSS software version 16. Normality of data was assessed using Kolmogorov-Smirnov test. T and ANOVA tests were used if data had normal distribution. Mann-Whitney U or Kruskal-Wallis tests were used for the remaining data. Correlation between qualitative variables was evaluated by Chi-square test. The mean [ +/- SD] age and disease activity of the patients were 37.72 [ +/- 12.18] years and 4.78 [ +/- 1.98], respectively. There were no correlation between disease activity and mean age Low bone density was seen in 30.8%, 11 .5%, and 15.4% in spine, femur neck, and hip, respectively. There was no relationship between Z-score of total hip, spine, and femur neck with disease activity, age, and duration of disease [p>0.05]. Our results showed an acceptable rate of low bone density in patients with ulcerative colitis without any correlation with the disease activity index
ABSTRACT
It has been reported that 15-20% of parous female have experienced at least one miscarriage, while 3% of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a his-tory of spontaneous abortions. In this case-control study, 82 women with a history of two or more abortions referred to the six private gynecologic clinics in Gorgan city without any structural abnormality were recruited during 201 1-2012. Plasma levels of antithrom-bin III [ATIII] using colorimetric assay, protein C, protein S, factor V Leiden and lupus anticoagulant [LAC] using coagulation method were measured. The control group was women with a history of normal delivery and no abortions. Those under anti-coagulant therapy were excluded from the study. Data were entered into the computer using the Statistical Package for the Social Sciences [SPSS, SPSS Inc., Chicago, IL, USA] version 16 and analyzed by Chi-square, t test and non-parametric tests. At least one abnormality was reported in 35 cases [42.7%]. Among them, protein C deficiency was the most prevalent [30.5%]. ATIII was abnormal in 17.1% and lupus anti-coagulant was abnormal in 8.5%. Factor V Leiden was normal in all cases and protein S deficiency was only seen in one case. We suggest to perform these tests in regards to the thrombophilia in cases with spontaneous abortions in order to find an early cure for this treatable disorder
ABSTRACT
Leiomyoma is the most common benign tumor of the uterus and could complicate pregnancy. Here we present a case of leiomyoma in a nullipara women at the 24[th] week of gestation complained of abdominal pain and nausea which was not responding to conservative therapies. A laparotomy was done and a 30*20 cm mass was resected from the uterus. She had a normal term delivery after the operation